소목(Caesalpinia sappan) 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성 억제에 미치는 영향
Effects of Caesalpinia sappan extracts on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans
유용욱, 유현희, 김윤정, 유미선, 서세정, 이황, 이흥수,
소속 상세정보
유용욱 ( ) - 원광대학교 치과대학 구강생화학교실
유현희 ( ) - 원광대학교 치과대학 구강생화학교실
김윤정 ( ) - 원광대학교 치과대학 예방치학교실
유미선 ( ) - 원광대학교 치과대학 예방치학교실
서세정 ( ) - 원광대학교 치과대학 구강생화학교실
이황 ( ) - 원광대학교 치과대학 구강생화학교실
이흥수 ( ) - 원광대학교 치과대학 예방치학교실
KMID : 0355420030270020277
Abstract
Streptococcus mutans is known as the causative bacterial playing the most important role in forming plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of chloroform extract(CE), n-butanol extract(BE), methanol extract(ME) and water extract(WE) of Caesalpinia sappan on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans. The CE, BE, ME and WE decreased the growth and acid production of S. mutans than that of control, especially, the ME was more effective than other extracts. The effect of CE, BE, ME and WE on the adherences to saliva-coated hydroxyapatite bead(S-HA) were evaluated, At the concentration of 2,000 pg/ml, the CE showed 32% rate of bacterial adherence to S-HA, whereas, other extracts of the same concentration produced greater than 50% rate. The CE and BE were significantly decreased the reduction rates of water insoluble glucan formation from sucrose by crude glucosyltransferase of S. mutans. Thus, the application of C. sappan can be considered a useful and a practical method for the prevention of dental caries.
키워드
구강다형연쇄상구균;소목 추출물;치아우식 예방;향균력;antibacterial effect;Caesalpinia sappan;dental caries;Streptococcus mutans
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